Vaccine makers use more than a billion fertilised hens' eggs a year, and Ovagen's EIC report says up to 30% of eggs used in vaccine production carry bacteria inside them. A single contaminated egg can destroy a vaccine batch, at a cost the report puts at up to $480,000. Ovagen, based in Ballina, County Mayo, has worked since 2000 on raising germ-free hens that lay sterile eggs.
In June 2022 the company announced €10 million from the EIC: a €2.5 million grant and €7.5 million in equity. The grant funded Ovavax2, a €3.6 million project from November 2022 to October 2024 to bring germ-free eggs "into mass production". In February 2023 Ovagen told the Irish Examiner it expected to produce up to four million eggs a year by 2026-27, with revenue of €42 million, and to grow from 12 to 75 staff by 2026. In October 2024 it had 17 staff and a new target of 77 by 2029, according to Silicon Republic.
Company file
- Legal entity
- Ovagen Group Limited, Ballina, County Mayo, Ireland
- Work began
- 2000
- CEO and co-founder
- Catherine Caulfield
- Product
- Germ-free and SPF eggs for vaccine production and research
- Earlier EU funding
- H2020 SME Instrument Phase 2, €2.36M
- EIC project
- Ovavax2, 1 Nov 2022 to 31 Oct 2024, closed
- EIC funding
- Blended finance: €2.5M grant, €7.5M equity announced
Where Ovagen Stands Now
In October 2024 the Western Development Commission led a €2 million Series A with IRRUS, HBAN, Boole, DeepIE, Spark Crowdfunding and Enterprise Ireland; the company said it had raised more than €21 million since its founding. In August 2026 it announced that the US Department of Agriculture had approved a health certificate for exporting its research eggs to the US, and that Peru had set import requirements for Irish SPF eggs. Neither announcement names a customer or an order.
"What we have developed isn't incremental, it's a complete rethink of the vaccine manufacturing process."
Catherine Caulfield, CEO, Ovagen, July 2025The Technology: Eggs Without Bacteria
Vaccine makers today buy specific pathogen-free (SPF) eggs. Ovagen instead raises germ-free birds in isolators, reaching three generations of birds by 2013, so that their eggs are free of bacteria. In the EIC report its eggs grew H1N1 flu virus with "yields up to 2-fold higher" than standard suppliers, and an animal vaccine maker confirmed they were "sterile on arrival". In July 2025 the company reported a study with the Pirbright Institute in which its eggs yielded 7,606 doses of yellow fever vaccine per egg, against 422 and 6 in eggs from two SPF suppliers it did not name.
What the EIC Project Promised, and What CORDIS Shows
Ovavax2 set out to produce "the world's first Germ Free egg and bringing it into mass production", to extend testing from influenza to COVID-19, yellow fever and Newcastle disease, and to scale production internationally. The final report gives the H1N1 result and customer feedback, and says material transfer agreements were signed with vaccine makers, contract manufacturers and research organisations to evaluate the eggs. It reports no production volume, no supply contract and no commercial scale-up.
- Higher yields than SPF eggsShownH1N1 and yellow fever.
- Customer evaluationsUnder wayMaterial transfer deals.
- Mass productionNot shownNo volumes reported.
- 75 staff by 2026Moved to 202917 in October 2024.
The Money
Ovagen's timeline records €1.4 million in early rounds, an €8 million round between 2004 and 2008, €2.36 million from the EU's SME Instrument and the EIC's €10 million package. Whether the €7.5 million EIC equity has been invested is not public; the EIC Fund was not named among the Series A investors. Ovagen does not publish revenue.
What Cannot Be Checked
Questions for the EIC
Whether the EIC Fund paid in the €7.5 million equity, how many eggs Ovagen sells and to whom, and its revenue against the €42 million forecast are not public.
Why Europe Should Care
The EIC project tied germ-free eggs to pandemic preparedness, and Ovagen calls its product the world's first. The EU has backed it twice, through the SME Instrument and the EIC, and it has reported better yields; the commercial scale the EIC paid for has not been shown.
What the project promised
Germ-free eggs in mass production, four million a year and €42 million in revenue by 2026-27.
What the record shows
Strong yield studies, material transfer agreements, export approvals, 17 staff in 2024 and no published sales.
The Verdict
Better eggs, no scale yet
Ovagen's science reports striking yields. Two years after the EIC project, the company that promised mass production and €42 million in revenue had not published a single sale, and it has pushed its hiring plan back three years.
Ovagen and the EIC have not been asked for comment for this article. It is based entirely on public records and published statements, linked throughout.
Sources
- CORDIS, Ovavax2 fact sheet and report
- Ovagen, EIC award, June 2022
- Ovagen, company timeline
- Irish Examiner, four million germ-free eggs, February 2023
- RTÉ, WDC leads €2m investment, October 2024
- Silicon Republic, Ovagen raises €2m, October 2024
- Ovagen, Pirbright study, July 2025
- Ovagen, USDA approval, August 2026 and Peru, August 2026
